Charlie has struggled with drug abuse for a while. On May 20, 1998, he injected himself with cocaine, accidentally giving himself an overdose. He was hospitalized, but discharged from the hospital soon afterward. His father Martin issued a public appeal for fans to pray for him and reported him for violating his parole. A warrant was issued for his arrest, and Sheen was sent to rehab.

In February 2010, Sheen announced that he would take a break from Two and a Half Men to voluntarily enter a rehab facility. In March, Sheen's press representatives announced that he was preparing to leave rehab and return to work on the popular sitcom. On May 18, 2010, Sheen signed an agreement to return to the sitcom for another two years for a reported $1.8 million per episode.

On January 28, 2011, Sheen began undergoing a substance rehabilitation program in his home and CBS announced that Two and a Half Men would go into hiatus. The network subsequently announced that the season then underway and due to film its last four episodes was canceled after Sheen made offensive comments about the creator and lead writer of Two and a Half Men, Chuck Lorre, on the February 24 edition of a radio broadcast hosted by Alex Jones.

On February 28, 2011, Sheen publicly demanded a 50 percent raise for the show "Two and a Half Men" on a national television interview in his home. Although he is already the highest paid actor on television, Sheen demanded 3 million dollars per episode, claiming that in comparison to the amount that the series is making he is "underpaid".

On March 7, 2011, CBS and Warner Bros. fired Sheen from Two and a Half Men.

Charlie took to the internet on Ustream for a web show he calls Sheen’s Korner, where he broadcasts live from his home. He rants and vents about the “trolls” who are against him and continues with his “winning” attitude.

• Real name: Carlos Irwin Estevez
• Birth date: September 3, 1965
• Birth place: New York City, NY