B.T.K. – Arguably the scariest serial killer of recent vintage is the BTK (short for Bind, Torture, Kill) Killer Dennis Rader, the inspiration for the horror biopic B.T.K.
The Dentist – Allegedly based on a real dentist-turned-serial-killer (or is that vice versa?), this is a movie to avoid if you’re already afraid of the dentist.
Henry: Portrait of a Serial Killer – The crimes and delusional fantasies of Henry Lee Lucas were the primary source of inspiration for this lastingly infamous horror movie.
Gacy – Crimes don’t get much more tailor-made for horror movies than those committed by notorious killer clown John Wayne Gacy.
Eaten Alive – Tobe Hooper’s follow-up to The Texas Chainsaw Massacre was based on another real-life Texas killer: Joe Ball, aka The Alligator Man.
Curse of the Zodiac – More respectable films have been inspired by the serial killer known as Zodiac, but this is the grimy horror movie answer to the Fincher movie.
Psycho – The granddady of real-life horror monsters would have to be Ed Gein, the small town serial killer who partly inspired novelist Robert Bloch to write the novel that eventually became Alfred Hitchcock’s Psycho.